Interference with the Signaling Capacity of Cc Chemokine Receptor 5 Can Compromise Its Role as an HIV-1 Entry Coreceptor in Primary T Lymphocytes

In this issue of The Journal of Experimental Medicine ([1][1]), Alfano et al. report the surprising results that pertussis toxin (PTX) as well as its cellular binding subunit, the B-oligomer, each blocked entry of monotropic (R5) strains of HIV-1 in primary T lymphocytes. Treatment of primary T