The left or right uterine artery was ligated in 100 rats on Day 4, 5, 6, 7, 8, 9, 10 or 12 of gestation. Uterine arterial ligation had no apparent effect on survival, malformation or sex ratios of fetuses examined on Day 22. There was a small decrease in fetal weight and an increase in placental weight particularly after ligation on Day 9. Placental hypertrophy, as an adaptation to impaired uterine circulation, is discussed.
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N. W. Bruce (1976) studied this question.
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