April 25, 2008Biochemical Journal

Endoplasmic reticulum Ca2+ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+ release

View Full Paper

Ask AI

Bookmark

Population

HEK-293 cells expressing RyR2 mutations or wild-type

Comparison

Expression of RyR2 mutations vs Cells expressing RyR2 wild-type

Design

Preclinical

Authors

PJPeter P. JonesElectrophysiology DJDawei Jiang82th Hospital of Pla JBJeff BolstadUniversity of Calgary

Discussion

Member takes

Implication

Alters SOICR threshold as common RyR2 arrhythmia mechanism in animal models; hypothesis-generating, does not yet inform clinical practice.

Structured PICO

Population

HEK-293 cells (human embryonic kidney cells) expressing RyR2 (cardiac ryanodine receptor) mutations or wild-type

Intervention

Expression of RyR2 mutations (V4653F, R176Q/T2504M, S2246L, Q4201R, A4860G)

Comparator

Cells expressing RyR2 wild-type

Outcome

Luminal Ca2+ threshold for store-overload-induced Ca2+ release (SOICR)surrogate

Alteration of the threshold for store-overload-induced Ca2+ release is a common cellular mechanism underlying RyR2-associated ventricular arrhythmias.

Cite This Study

Jones et al. (2008) studied this question.

synapsesocial.com/papers/6a8906f36fb350aba9126a1c https://doi.org/10.1042/bj20071287

View Full Paper

Ask AI

Bookmark

Implication

Alters SOICR threshold as common RyR2 arrhythmia mechanism in animal models; hypothesis-generating, does not yet inform clinical practice.

Endoplasmic reticulum Ca2+ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+ release

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endoplasmic reticulum Ca2+ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+ release

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider