Modulation of gingival cAMP levels by tissue infalmmation

The basal levels of the nucletide cAMPin gingiva and the relationship of these levels to gingival tissue health was determined in Rhesus monkeys. It was shown that tissue cAMP levels were negatively correlated ot gingival infalmmation. Infalmed gingiva showed lower tissue cAMP levels that healthy gigiva. In adition, the effect of thetrauma of in the tissues progressively decreased as flaps were reflected for 30,60, or 120 minutes. It is concluded that inflammatory stimuli due to bacterial plaque or tissue trauma both result in lowered tissue cAMP levels which may be one of teh mediators of the physiologic changes seen in gingival tissuess during infalmmation.