SSTR2 is the most efficient somatostatin receptor subtype for coupling to GIRK1 channels, supporting its role in activating potassium conductances in vivo.
SSTR2 prioritization for GIRK studies in electrophysiology models; hypothesis-generating and requires native tissue validation before any clinical inference.
The five different rat somatostatin receptor subtypes (SSTR1-SSTR5) were coexpressed with a subunit of G-protein gated inwardly rectifying potassium channel (GIRK1) in Xenopus oocytes. SSTR2-SSTR5, but not SSTR1 coupled efficiently to the activation of GIRK currents when stimulated by SST14 or SST28. A comparison of the dose-response curves and of the maximum currents obtained indicates that SSTR2 couples most efficiently to this effector, supporting the notion that SSTR2 is involved in activation of potassium conductances by SST in vivo.
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Kreienkamp et al. (1997) studied this question.
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