Heavy Particles and the Bragg Peak in Therapy

Special Article1 February 1965Heavy Particles and the Bragg Peak in TherapyJOHN H. LAWRENCE, M.D., D.SC., F.A.C.P., CORNELIUS A. TOBIAS, PH.D., JOHN A. LINFOOT, M.D., JAMES L. BORN, M.D., ELWARD MANOUGIAN, M.D., JOHN LYMANJOHN H. LAWRENCE, M.D., D.SC., F.A.C.P.Search for more papers by this author, CORNELIUS A. TOBIAS, PH.D.Search for more papers by this author, JOHN A. LINFOOT, M.D.Search for more papers by this author, JAMES L. BORN, M.D.Search for more papers by this author, ELWARD MANOUGIAN, M.D.Search for more papers by this author, JOHN LYMANSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-2-400 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is indeed a pleasure and an honor to be asked to deliver a lecture honoring Dr. E. P. Richardson. He was our teacher during my third year of medical school and was in charge of bedside surgical rounds. He epitomized to all of us the finest in medicine and was himself a fine example of Harvard medical tradition.Before discussing recent clinical studies using heavy particles in therapy, we shall summarize more than 25 years' experience with them. For the first time, in the summer of 1935, I saw Wilson cloud chamber pictures demonstrating visually the ability of heavy...References1. LAWRENCELAWRENCE JHEO: The biological action of neutron rays. Proc. Nat. Acad. Sci. USA 22: 124, 1936. CrossrefMedlineGoogle Scholar2. LAWRENCETENNANT JHR: Comparative effects of neutrons and X-rays on whole body. J. Exp. Med. 66: 667, 1937. CrossrefMedlineGoogle Scholar3. LAWRENCEAEBERSOLDLAWRENCE JHPCEO: The comparative effects of X-rays and neutrons on normal and tumor tissue. Proc. Nat. Acad. Sci. USA 22: 543, 1936. CrossrefMedlineGoogle Scholar4. AXELRODAEBERSOLDLAWRENCE DPCJH: Comparative effects of neutrons and X-rays on 3 tumors irradiated in vitro. Proc. Soc. Exp. Biol. Med. 48: 251, 1941. CrossrefGoogle Scholar5. STONELAWRENCEAEBERSOLD RSJHPC: Preliminary report on use of fast neutrons in treatment of malignant disease. Radiology 35: 322, 1940. CrossrefGoogle Scholar6. HUBBARD EL: Heavy ion accelerators. Ann. Rev. Nucl. Sci. 11: 419, 1961. CrossrefGoogle Scholar7. KELLY EL: General description and operating characteristics of the Berkeley 88-inch cyclotron. Nucl. Instr. Meth. 18-19: 33, 1962. CrossrefGoogle Scholar8. SILLESENLAWRENCELYMAN KJHJT: Heavy-particle ionization (H, He, Li, B, C, N, O, F, Ne, Ar) and the proliferative capacity of neoplastic cells in vivo. Semi-Annual Report, UCRL-11033 Donner Laboratory, University of California Lawrence Radiation Laboratory, Berkeley, 1963, pp. 139-151. Also in Acta Isotop. (Padova) 3: 107, 1963. Google Scholar9. D'ANGIOLAWRENCEGOTTSCHALKLYMAN GJJHAJT: The relative efficiency of high-LET radiations (Bragg-peak lithium ions) on normal rabbit skin using integral dose as a basis for comparison. Semi-Annual Report, UCRL-11387, Donner Laboratory, University of California, Berkeley, 1964, pp. 127-139. Google Scholar10. LEA DE: Actions of Radiations on Living Cells, Macmillan Co., New York, 1947. Google Scholar11. GRAY LH: The influence of oxygen on the response of cells and tissues to ionizing radiation. Lect. Sci. Basis Med. 7: 314, 1957-58. Google Scholar12. D'ANGIOLAWRENCE GJJH: Medical research with high-energy heavy particles. Nucleonics 21: 56, 1963. Google Scholar13. LAWRENCETOBIAS JHCA: Heavy particles in medicine, in Progress in Atomic Medicine, Grune & Stratton, New York, 1965. In press. Google Scholar14. TOBIASANGERLAWRENCE CAHOJH: Radiological use of high-energy deuterons and alpha particles. Amer. J. Roentgen. 67: 1, 1962. Google Scholar15. LAWRENCETOBIASBORNWANGLINFOOT JHCAJLCCJA: Heavy particle irradiation in neoplastic and neurologic disease. J. Neurosurg. 19: 717, 1962. CrossrefMedlineGoogle Scholar16. LAWRENCENELSONWILSON JHWOH: Roentgen irradiation of the hypophysis. Radiology 29: 446, 1937. CrossrefGoogle Scholar17. LAWRENCETOBIAS JHCA: Radioactive isotopes and nuclear radiations in treatment of cancer. Cancer Res. 16: 185, 1956. MedlineGoogle Scholar18. LAWRENCE JH: Proton irradiation of the pituitary. Cancer 10: 795, 1957. CrossrefMedlineGoogle Scholar19. LAWRENCETOBIASBORNSANGALLICARLSONLINFOOT JHCAJLFRAJA: Heavy particle therapy in acromegaly. Acta Radiol. (Stockholm) 58: 337, 1962. CrossrefGoogle Scholar20. LAWRENCETOBIASLINFOOTBORNGOTTSCHALKKLING JHCAJAJLARP: Heavy particles, the Bragg curve and the suppression of pituitary function in diabetic retinopathy. Diabetes 12: 490, 1963. CrossrefMedlineGoogle Scholar21. LINFOOTLAWRENCEBORNTOBIAS JAJHJLCA: Alpha-particle or proton beam in radiosurgery of the pituitary gland for Cushing's disease. New Eng. J. Med. 269: 597, 1963. CrossrefMedlineGoogle Scholar22. LAWRENCETOBIASBORNGOTTSCHALKLINFOOTKLING JHCAJLAJARP: Alpha particle and proton beams in therapy. JAMA 186: 236, 1963. CrossrefMedlineGoogle Scholar23. RAYHORWITH BSM: Surgical treatment of acromegaly, in Clinical Neurosurgery: Proceedings of the Congress of Neurological Surgeons, Williams and Wilkins Co., Baltimore, 1964, pp. 31-59. CrossrefGoogle Scholar24. JOPLINFRASERSTEINERLAWSLAWSJONES GFRRRJE: Partial pituitary ablation by needle implantation of gold-198 seeds for acromegaly and Cushing's disease. Lancet 2: 1277, 1961. CrossrefMedlineGoogle Scholar25. MCCULLAGHBECKSCHAFFENBURG EJCCA: Control of diabetes and other features of acromegaly following treatment with estrogens. Diabetes 4: 13, 1955. CrossrefMedlineGoogle Scholar26. CORDES FC: The diabetic: his visual prognosis. Arch. Ophthal. 48: 531, 1952. CrossrefGoogle Scholar27. BEETHAM WP: Visual prognosis of proliferating diabetic retinopathy. Brit. J. Ophthal. 47: 611, 1963. CrossrefMedlineGoogle Scholar28. CAIRDGARRETT FICJ: Prognosis for vision in diabetic retinopathy. Diabetes 12: 389, 1963. CrossrefMedlineGoogle Scholar29. GOTTSCHALKLYMANMCDONALD AJTLW: Use of the Bragg peak for brain-tumor therapy. Semi-Annual Report, UCRL-11184 Donner Laboratory, University of California, Berkeley, 1963, pp. 121-127. Google Scholar30. FALKMERFORSLARSSONLINDELLNAESLUNDSTENSON SBBAJS: Pilot study on proton irradiation of human carcinoma. Acta Radiol. (Stockholm) 58: 33, 1962. CrossrefMedlineGoogle Scholar31. KJELLBERGKOEHLERPRESTONSWEET RNAMWMWH: Biological and clinical studies using the Bragg peak of the proton beam. Paper presented at the Second International Congress of Radiation Research, Harrogate, Yorkshire, Eng., August 11 1962. Google Scholar32. CONCANNONKRAMERBERRY JPSR: The extent of intracranial gliomata at autopsy and its relationship to techniques used in radiation therapy of brain tumors. Amer. J. Roentgen. 84: 99, 1960. Google Scholar33. MALISLOVINGERKRUGERROSE LIRLJE: Production of laminar lesions in the cerebral cortex by heavy ionizing particles. Science 126: 302, 1957. CrossrefMedlineGoogle Scholar34. LARSSONLEKSELLREXEDSOURANDERMAIRANDERSSON BLLBPWB: The high energy proton beam as a neurosurgical tool. Nature 182: 1222, 1958. CrossrefMedlineGoogle Scholar35. LEKSELLLARSSONANDERSSONREXEDSOURANDERMAIR LBBBPW: Lesions in the depth of the brain produced by a beam of high energy protons. Acta Radiol. (Stockholm) 54: 251, 1960. CrossrefMedlineGoogle Scholar36. LARSSONLEKSELLREXED BLB: The use of high energy protons for cerebral surgery in man. Acta Chir. Scand. 125: 1, 1963. Google Scholar37. VAN DYKEJANSSEN DCP: Removal of cerebral cortical tissue with negligible scar formation using a beam of high-energy particles. J. Neurosurg. 20: 280, 1963. Google Scholar38. FOWLERPERKINS PHDH: The possibility of therapeutic applications of beams of negative π-mesons. Nature 189: 524, 1961. CrossrefMedlineGoogle Scholar39. RICHMANACETORAJUSCHWARTZWEISSBLUTH CHMRBM: On the dosimetry of negative pions with a view toward their use in cancer therapy. Semi-Annual Report, UCRL-11387, Donner Laboratory, University of California, Lawrence Radiation Laboratory, Berkeley, 1964, pp. 114-126. Google Scholar40. SIEGBAHNHOWARD KFT: Sector-focused cyclotrons, in Proceedings of the International Conference on Sector-Focused Cyclotrons, University of California, Los Angeles, April 17-20, 1962, North-Holland Publishing Co., Amsterdam, 1962. Google Scholar41. GORDONBEHMAN HSGA: Particle accelerators. American Institute of Physics Handbook, 2nd ed., McGraw-Hill Book Co., New York, 1963, section 8i, pp. 168-222. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Berkeley, CaliforniaFrom the Donner Laboratory and Lawrence Radiation Laboratory, University of California, Berkeley, Calif.This report is based on the Richardson Memorial Lecture presented at the Massachusetts General Hospital, Boston, Mass., on May 31, 1963.Requests for reprints should be addressed to John H. Lawrence, M.D., Donner Laboratory, University of California, Berkeley, Calif. 94720. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAn Overview of Hypofractionation and Introduction to This Issue of Seminars in Radiation OncologyHigh yields of isochromatid breaks and successive formation of chromosome exchanges may lead to reproductive cell death following high-LET irradiationDesigning, Building and Installing a Stereotactic Radiosurgery UnitDie AdenohypophyseIsah: A versatile treatment positioner for external radiation therapyBragg Peak Proton Beam Irradiation of the Pituitary Gland for Proliferative Diabetic RetinopathyCHOODAPPA S. MUNICHOODAPPA, M.D., F.R.C.P.(C), SEARLE B. REES, M.D., ROBERT F. BRADLEY, M.D., F.A.C.P., MARIOS C. BALODIMOS, M.D., GUENTHER BODEN, M.D.Therapy with high-energy heavy particlesTherapy with high-energy heavy particlesBrain TumorsAcromegaly pre- and postpituitary irradiationHormones of the Anterior Pituitary Body 1 February 1965Volume 62, Issue 2Page: 400-407KeywordsAttentionBiologicsEngineersPhysicistsRadiation therapyResearch laboratories Issue Published: 1 February 1965 PDF DownloadLoading ...