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About 30 years ago, Goldblatt (1, 2) and von Euler (3, 4) showed that human and ovine seminal plasma contain an acidic lipid (prostaglandin) with vasodepressor activity and smooth muscle-stimu- lating activity. The early studies have been sum- marized by von Euler (5, 6). In 1960 Berg- strom and Sjdvall isolated from sheep vesicular glands a highly potent crystalline material, prostaglandin E1 (PGE1) Further studies showed that
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Steinberg et al. (1964) studied this question.
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