Design and Implementation of an Efficient Synthetic Approach to Pyranosylated Indolocarbazoles: Total Synthesis of (+)-RK286c, (+)-MLR-52, (+)-Staurosporine, and (−)-TAN-1030a

A total synthesis of the natural products (+)-staurosporine ( 2 ), (+)-RK286c ( 3 ), (−)-TAN-1030a ( 4 ), and (+)-MLR-52 ( 5 ) has been achieved. The synthetic strategy involves the stereoselective ring expansion of a furanosylated indolocarbazole [(+)- 8 ] to a pyranosylated congener [(+)- 12 ] that serves as a common intermediate in the production of 2 − 5 .