Why the study?
Does acute metabolic acidosis induced by HCl alter pulmonary vascular resistance and pulmonary arterial pressure in broilers?
Population
Lightly anesthetized clinically healthy male broilers
Comparison
Acute metabolic acidosis induced by bolus i.v… vs 2.5% mannitol (volume control)
Design
Preclinical
Authors
Loading...
Acute metabolic acidosis alters pulmonary hemodynamics rate-dependently in broilers; leaves open translation to mammalian or clinical pulmonary hypertension models.
Does acute metabolic acidosis induced by HCl alter pulmonary vascular resistance and pulmonary arterial pressure in broilers?
Acute metabolic acidosis induces pulmonary hypertension in broilers through rate-dependent mechanisms, with bolus injections causing transient vasoconstriction and constant infusions increasing cardiac output.
Wideman et al. (1998) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: