Identifies a region on chromosome 9 associated with ascites susceptibility and ventricular hypertrophy in broiler chickens, highlighting AGTR1 and UTS2D as candidate genes.
May guide selective breeding against ascites in broilers; leaves open functional validation and translational relevance to human cardiovascular disease.
A genome-wide SNP survey was used to identify chromosomal regions that showed linkage disequilibrium with respect to ascites susceptibility and ventricular hypertrophy in an F2 cross between previously described ascites-resistant and -susceptible lines. Variable number tandem repeats were used to obtain genotype data to further characterize these regions. A region on chromosome 9 (12 to 13 Mbp in 2011 assembly) shows association with ascites in the ascites lines and in several commercial broiler breeder lines with a significant sex effect. There are 2 candidate genes, AGTR1 (an angiotensin II type 1 receptor) and UTS2D (urotensin 2 domain containing), in this region that have been associated with hypertension and hypoxic response in mammals.
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Krishnamoorthy et al. (2014) studied this question.
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