Antigenicity of insulin: diabetes induced by specific antibodies

sensitized guinea pigs with ox or pig insulin. Using the Dale technique, he observed contractions of uterine strips from these animals in response to both ox and pig insulin. There was a more persistent response to the preparation of insulin which had been used to sensitize the animal. Wasserman & Mirsky (1942) showed that anaphylaxis could be induced in guinea pigs with insulin of a different species than that used for sensitization. Banting, Franks & Gairns (1938) reported the development of resistance to insulin in a non-diabetic schizophrenic patient following a course of insulin shock treat- ment. Blood serum from this patient, mixed with 12-2