Transition-Metal-Catalyzed Site-Selective C–H Functionalization of Quinolines beyond C2 Selectivity

Quinoline is an important scaffold in many natural products, biologically active compounds, and functional materials. The C–H functionalization of quinoline scaffolds by transition metal catalysis provides an efficient method for rapidly obtaining substituted quinolines. This review summarizes recently reported transition-metal-catalyzed site-selective C–H functionalization of quinolines, excluding C2 selective reactions. A review of direct functionalization of quinoline N -oxides at the C8 position also is provided.