Progression of Different Nasally Instilled Viruses along Different Nervous Pathways in the Same Host

Different neurotropic viruses instilled into the nose of the same host (mouse) can select different nervous path-ways for invading the central nervous system. The viruses of vesicular stomatitis and equine encephalomyelitis were shown to use the olfactory pathway but not the trigeminus, sympathetic, or parasympathetic pathways, while pseudorabic virus invaded along the latter three routes and not along the olfactory.