Why the study?
Central nervous system tumors cause high disability and mortality, while hydrogen sulfide plays a significant role in pathophysiology, tumor development, and neovascularization.
Hydrogen sulfide plays a role in the pathophysiology of central nervous system tumors by facilitating cancer cell growth and angiogenesis.
May support hydrogen sulfide pathway targeting in CNS tumors; leaves open clinical relevance pending prospective trials.
Central nervous system tumors are classified as diseases of special clinical significance with high disability and high mortality. In addition to cerebrovascular diseases and craniocerebral injuries, tumors are the most common diseases of the central nervous system. Hydrogen sulfide, the third endogenous gas signaling molecule discovered in humans besides nitric oxide and carbon monoxide, plays an important role in the pathophysiology of human diseases. It is reported that hydrogen sulfide not only exerts a wide range of biological effects, but also develops a certain relationship with tumor development and neovascularization. A variety of studies have shown that hydrogen sulfide acts as a vasodilator and angiogenetic factor to facilitate growth, proliferation, migration and invasion of cancer cells. In this review, the pathological mechanisms and the effect of hydrogen sulfide on the central nervous system tumors are introduced.
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Peng et al. (2021) studied this question.
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