Phagocytosis of small latex particles was demonstrated by light and electron microscopy in a proportion of cells from B-lymphoproliferative disorders including chronic lymphocytic, prolymphocytic and hairy cell leukaemia. It was not observed in a case of T-chronic lymphocytic leukaemia or in normal lymphocytes. A significant correlation was observed between the binding of latex to the lymphocyte surface and the degree of phagocytosis. It is suggested that the phagocytic activity of leukaemic B-lymphocytes is mediated through their Fc receptor and that this property may also be present in normal B-cells. Among mononuclear cells, therefore, phagocytosis can no longer be considered exclusively a property of monocytes.
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Catovsky et al. (1977) studied this question.
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