Cultured "Hairy Cells" Infected with Epstein-Barr Virus: Evidence for B-Lymphocyte Origin

Brief Reports1 January 1979Cultured "Hairy Cells" Infected with Epstein-Barr Virus: Evidence for B-Lymphocyte OriginSTANLEY M. LEMON, M.D., JOSEPH S. PAGANO, M.D., PETER D. UTSINGER, M.D., JOSEPH G. SINKOVICS, M.D.STANLEY M. LEMON, M.D.Search for more papers by this author, JOSEPH S. PAGANO, M.D.Search for more papers by this author, PETER D. UTSINGER, M.D.Search for more papers by this author, JOSEPH G. SINKOVICS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-1-54 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe origin of the malignant "hairy cells" of leukemic reticuloendotheliosis remains controversial (1). These cells are frequently capable of latex phagocytosis and glass or nylon adherence and also may possess surface receptors for cytophilic antibody, all properties of monocytes. However, they also possess receptors for complement (C3) and aggregated immunoglobulin, characteristics of both B lymphocytes and monocytes, and may synthesize membrane-bound surface immunoglobulins, a feature thought to be unique to B lymphocytes. The "hairy cell" may be derived from a unique, phagocytic subpopulation of B lymphocytes (1).A continuous cell line, designated 4972, was recently established from the spleen of...References1. UTSINGERYOUNTFULLERLOGUEORRINGER PWCME: Hairy cell leukemia: B-lymphocyte and phagocytic properties. Blood 49:19-27, 1977 CrossrefMedlineGoogle Scholar2. SINKOVICSGYÖRKEYGYÖRKEYWANG JFPC: Hairy cells in long-term cultures (letter). Ann Intern Med 85:532-533, 1976 LinkGoogle Scholar3. PAGANO J: The Epstein-Barr viral genome and its interactions with human lymphoblastoid cells and chromosomes, in Viruses, Evolution and Cancer, edited by KURSTAK E, MARAMOROSCH K. New York, Academic Press, 1974, p. 79 Google Scholar4. YOUNTUTSINGERHUTTBUCHANANKORNFULLERLOGUEPAGANO WPLPJCMJ: Subpopulations of human lymphoblastoid cell lines. Scand J Immunol 5:795-810, 1976 CrossrefMedlineGoogle Scholar5. HUANGPAGANO EJ: Nucleic acid hybridization technology and detection of proviral genomes, in Methods in Virology, vol. 6, edited by MARAMOROSCH K, KOPROWSKI H. New York, Academic Press, 1977, p. 457 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STANLEY M. LEMON, M.D.; JOSEPH S. PAGANO, M.D.; PETER D. UTSINGER, M.D.; JOSEPH G. SINKOVICS, M.D.Affiliations: M. D. Anderson Hospital Houston, Texas PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAdditional Mature B-Cell LinesEstablishment of a new cell line from a patient with hairy cell leukemia-japanese variantNew cell line from hairy-cell leukemia: Confirmation of leukemic cell origin by karyotype and IG gene analysisMicrobial oncogenesisHairy Cell Leukemia: Advances in the Immunologic Evaluation and Identification of a Normal Counterpart CellAnalysis of transformation with epstein-barr virus and phenotypic characteristics of lymphoblastoid cell lines established from patients with hairy cell leukemiaRestrictions upon epstein-barr virus infection of the leukemic cell are demonstrated in patients with hairy cell leukemiaAutologous Red Blood Cell and Platelet Engulfment in Hairy Cell LeukemiaHaarzell-LeukämieReferencesSubsets of hairy cell leukemia defined by unique membrane proteinsLeukemic reticuloendotheliosis (hairy cell leukemia): A review of the evidence concerning the immunology and origin of the cell 1 January 1979Volume 90, Issue 1Page: 54-55KeywordsB cellsCellsComplement receptorsEpstein-Barr virusLatexLymphocytesMonocytesPhagocytosisSpleen ePublished: 1 December 2008 Issue Published: 1 January 1979 PDF downloadLoading ...