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March 1, 1976Journal of Clinical InvestigationOpen Access

Adenosine deaminase activity in chronic lymphocytic leukemia. Relationship to B- and T-cell subpopulations.

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Why the study?

Does adenosine deaminase activity differ in lymphocytes from patients with chronic lymphocytic leukemia compared to normal subjects?

Population

Patients with chronic lymphocytic leukemia (CLL) and normal subjects

Comparison

Therapy for chronic lymphocytic leukemia vs Normal subjects

Design

Cohort

Authors

RTRobert TungCITIC Group (China)RSR SilberSupélecFQFranco QuagliataNovartis (Switzerland)

Discussion

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Implication

ADA activity tracks CLL burden reversibly; leaves open its prognostic value or therapeutic targeting.

Structured PICO

Does adenosine deaminase activity differ in lymphocytes from patients with chronic lymphocytic leukemia compared to normal subjects?

P
Population
Patients with chronic lymphocytic leukemia (CLL) and normal subjects
I
Intervention
Therapy for chronic lymphocytic leukemia (unspecified)
C
Comparator
Normal subjects
O
Outcome
Adenosine deaminase (ADA) level, phenotypes, and isozyme distribution in lymphocytessurrogate

Adenosine deaminase levels are decreased in untreated chronic lymphocytic leukemia due to the proliferation of abnormal B cells, and this anomaly is reversible with therapy.

Cite This Study

Tung et al. (1976) studied this question.

synapsesocial.com/papers/6a891f96ccf6b39be57b53aahttps://doi.org/10.1172/jci108334
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