A concise and totally synthetic route involving the merger of a fully deprotected glycosylamine and a minimally protected aspartic acid containing peptide has enabled the homogeneous N-linked glycopeptide 1 to be synthesized. The other key conversions in the synthesis are the progression from glycal to free oligosaccharide hemiacetal and subsequent amination with high efficiency.
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Wang et al. (2000) studied this question.
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