Why the study?
The study investigated whether three circulating miRNAs linked to diabetic polyneuropathy are also correlated with obesity.
Are expression levels of miR-128a, miR-155, and miR-499a associated with obesity in patients with Type 2 diabetes?
Are expression levels of miR-128a, miR-155, and miR-499a associated with obesity in patients with Type 2 diabetes?
Lower expression levels of miR-155 and miR-499a are associated with obesity and central obesity in patients with Type 2 diabetes, suggesting a potential role in obesity-driven pathogenetic mechanisms.
Background & aims: This study investigated a possible correlation between three circulating miRNAs, previously observed to be associated to diabetic polyneuropathy, and the obesity condition. Methods & results: The expression levels of miR-128a, miR-155 and miR499a were evaluated in 49 participants with Type 2 diabetes, divided into different groups based on the presence or absence of obesity and central obesity. The analyses revealed a significant decrease of miR-155 and miR-499a expression levels in obese subjects. In particular, the reduction appears to be even more significant in Type 2 diabetes subjects with central obesity. Conclusion: The results suggest that these miRNAs could be involved in obesity-driven pathogenetic mechanisms.
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Latini et al. (2024) studied this question.
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