Transdermal Nicotine for Ulcerative Colitis

Letters15 September 1997Transdermal Nicotine for Ulcerative ColitisYuichi Ando, MDYuichi Ando, MDNagoya University School of Medicine; Nagoya, JapanSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-6-199709150-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the report by Sandborn and colleagues [1] on the efficacy of transdermal nicotine for mildly to moderately active ulcerative colitis. They reported that the highest tolerated dosage of nicotine improved clinical activity but did not induce histologic remission.I am of the opinion that chronic effects by an intensive exposure to nicotine should be carefully assessed before patients received nicotine therapy in clinical practice. Several N-nitrosamines, such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), are synthesized from nicotine; these carcinogens would increase the risk for cancer [2, 3]. In Sandborn and colleagues' study, the serum levels of ...References1. Sandborn WJ, Tremaine WJ, Offord KP, Lawson GM, Petersen BT, Batts KP, et al. Transdermal nicotine for mildly to moderately active ulcerative colitis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1997; 126:364-71. Google Scholar2. Hecht SS, Chen CB, Ornaf RM, Jacobs E, Adams JD, Hoffmann D. Reaction of nicotine and sodium nitrite: formation of nitrosamines and fragmentation of the pyrrolidine ring. Journal of Organic Chemistry. 1978; 43:72-6. Google Scholar3. Amin S, Desai D, Hecht SS, Hoffmann D. Synthesis of tobacco-specific N-nitrosamines and their metabolites and results of related bioassays. Crit Rev Toxicol. 1996; 26:139-47. Google Scholar4. Benowitz NL, Porchet H, Sheiner L, Jacob P 3d. Nicotine absorption and cardiovascular effects with smokeless tobacco use: comparison with cigarettes and nicotine gum. Clin Pharmacol Ther. 1988; 44:23-8. Google Scholar5. Glickman RM. Inflammatory bowel disease: ulcerative colitis and Crohn's disease. In: Wilson JD, Braunwald E, Isselbacher KJ, Petersdorf RG, Martin JB, Fauci AS, et al, eds. Harrison's Principles of Internal Medicine. 12th ed. New York: McGraw-Hill; 1991:1268-81. Google Scholar Author, Article, and Disclosure InformationAuthors: Yuichi Ando, MDAffiliations: Nagoya University School of Medicine; Nagoya, Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGTS-21, an α7nAChR agonist, increases pulmonary bacterial clearance in mice by restoring hyperoxia-compromised macrophage functionThe α7 Nicotinic Acetylcholine Receptor Agonist GTS-21 Improves Bacterial Clearance in Mice by Restoring Hyperoxia-Compromised Macrophage FunctionPresence of a marked nonneuronal cholinergic system in human colon: Study of normal colon and colon in ulcerative colitisThe vagus nerve and the nicotinic anti-inflammatory pathwayAutonomic neural regulation of immunityCholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis 15 September 1997Volume 127, Issue 6Page: 491-492KeywordsCancer risk factorsCarcinogensNicotineUlcerative colitis ePublished: 15 August 2000 Issue Published: 15 September 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...