Low-Dose Ketamine and Diazepam: Use as an Adjunct to Local Anesthesia in an Office Operating Room

I evaluated the response of 200 patients undergoing office surgery to low-dose ketamine hydrochloride and diazepam as an adjunct to local anesthesia. In most patients, there was a slight increase in pulse rate and BP, but this was relatively mild. In almost all patients, there were no unpleasant recollections of the operative procedure, and I concluded that combination low-dose diazepam and ketamine is an effective and safe adjunct to local anesthesia in an office operating room facility.