Comparative study reveals elevated maternal serum free beta-hCG levels in twin pregnancies, indicating improved accuracy for Down syndrome prenatal screening.
Free beta-human chorionic gonadotrophin values are, on average, 1.90 times greater in twin pregnancies than in singleton pregnancies [95 per cent confidence interval (CI) 1.69-2.13]. This information can be used in screening for Down's syndrome, so that twin pregnancies can be interpreted in addition to singleton pregnancies.
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Wald et al. (1994) studied this question.
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