The structure of sanguinarine free base was examined. The base is either bis[6-(5,6-dihydrosanguinarinyl)] ether ( 3 ) or bis[6-(5,6-dihydrosanguinarinyl)]amine ( 4 ) depending on whether Na 2 CO 3 or NH 3, respectively, is used as an alkalizing agent. Oxysanguinarine ( 5 ) was identified as a side product formed by disproportionation of the pseudobase intermediate 2a .
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Dostál et al. (1996) studied this question.
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