Why the study?
Does ACEI use increase severe hypotension or vasopressor requirement in patients undergoing TKA with spinal anesthesia?
Does ACEI use increase severe hypotension or vasopressor requirement in patients undergoing TKA with spinal anesthesia?
No association found between ACEI use and severe hypotension or vasopressor needs in spinal TKA; leaves open need for prospective confirmation.
Purpose: To determine if patients on angiotensin-converting enzyme inhibitors (ACEIs) had more severe hypotension or required higher doses of vasopressors compared to those who were not on ACEIs under spinal anesthesia for total knee arthroplasty (TKA). Methods: A retrospective chart review of 169 patients who underwent TKA with spinal anesthesia between August 2012 and December 2014 was performed. The patients were divided into two groups, i.e. patients on ACEIs (ACEIs group) and patients not on ACEIs (non-ACEIs group), for comparison. The preoperative characteristics, anesthesia records, and postoperative outcomes were reviewed.
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Pang et al. (2016) studied this question.
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