The old switcheroo: The switch in the enantioselectivity of a reaction by using a single chiral source has been achieved using different metal binding modes of the chiral amino alcohol 1 in the presence of CuI and AgI sources. Azomethine ylides were shown to undergo highly enantio- and diastereoselective 1,3-dipolar cycloadditions with substituted tert-butyl acrylates to provide both of the enantiomerically enriched pyrrolidines (see scheme).
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Kim et al. (2009) studied this question.
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