Renoprotection by enzyme replacement therapy

aSamuel A. Levine, Professor of Medicine, Harvard Medical School, Boston, Massachusetts, USA and bProfessor of Nephrology, Necker Hospital, University of Paris V-Rene Decartes, Paris, France Correspondence to Dr B Brenner, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA Tel: +617 732 5850; fax: +617 582 6146; e-mail: [email protected] Abbreviations α-GAL: α-galactosidase αGAL-a: agalsidase alfa αGAL-b: agalsidase beta ERT: enzyme replacement therapy ESRD: end-stage renal disease rhα-GAL: recombinant human α-galactosidase