Clearance from the Respiratory Tract. SCHLESINGER, R. B. (1985). Fundam. Appl. Toxicol. 5, 435–450. Clearance is an essential component of the defense system of the respiratory tract. Alterations in the clearance of insoluble particles have been shown to provide a sensitive indicator of response due to exposure to various inhaled materials. This paper reviews clearance mechanisms, the significance of clearance changes, and the methodology used to assess them
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Richard B. Schlesinger (1985) studied this question.