Population
Mongrel dogs
Design
Preclinical
Follow-up
48 hours
Authors
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Pertussis toxin-treated dogs provide a preclinical model for Gi/Go signaling studies; leaves open translation to human autonomic or cardiac research.
In vivo treatment of dogs with pertussis toxin provides a whole animal model for studying Gi- and Go-mediated biochemical mechanisms and inhibitory regulation of adenylate cyclase.
Fleming et al. (1988) studied this question.
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