Treatment of Endometriosis and Other Gynecologic Conditions with Large Doses of Estrogens

THE use of stilbestrol in the treatment of endometriosis was described in 1948 by Karnaky1 and Hurxthal and Arnold.2 The purpose of this report is to relate further experience with the use of this drug in the treatment of endometriosis and in a few other conditions.In their original communication, Hurxthal and Arnold2 described 3 cases in which stilbestrol was tolerated with favorable results. The first patient in whom endometriosis was verified remains well and is amenorrheic after treatment for five years. Nodules cannot be palpated on pelvic examination. On several occasions, the drug has been discontinued, and painful menstruation . . .