Centrally administered atrial natriuretic factor exerts its diuretic and natriuretic effects at least partially through a dopaminergic mechanism.
Central ANF natriuresis may involve dopamine in animals; leaves open translation to human cardiorenal disease.
Intracerebroventricular administration of either rat atrial natriuretic factor (99-126) or dopamine to conscious male hydrated rats resulted in an increase in urinaryvolume and sodium excretion. This activity was prevented, in both cases, by nonselective dopamine antagonist haloperidol (2.5 or 1.25 mg/kg sc, 18 and 2 hr before intracerebroventricular administration of atrial natriuretic factor). Our findings suggest that atrial natriuretic factor exerts its centrally mediated effects on sodium and water metabolism, at least in part, via a dopaminergic mechanism.
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Torres et al. (1989) studied this question.
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