Why the study?
Does long-term administration of dobutamine compared to isoproterenol induce cardiac hypertrophy and fibrosis in mice?
Population
12-week-old C57BL/6 female mice
Comparison
Dobutamine 40 microg/mouse/day for 7 days vs Isoproterenol 40 microg/mouse/day for 7 days…
Design
Preclinical
Follow-up
7 days
Authors
Loading...
Chronic dobutamine may induce hypertrophy and fibrosis in mice; extends isoproterenol data but leaves open human translation.
Does long-term administration of dobutamine compared to isoproterenol induce cardiac hypertrophy and fibrosis in mice?
Chronic administration of dobutamine, similar to isoproterenol, induces cardiac hypertrophy, fibrosis, and decreased cardiac function in a mouse model.
Anderson et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: