Methyl Jasmonate: A Short Synthesis of Naturally Occurring Methyl Jasmonate and its Unnatural Enantiomer via Enantiodivergent Alkylation of Cyclopent‐2‐ene‐1,3‐diol Derivatives by Palladium(0)‐Induced Reactions Palladium‐catalyzed alkylation of cyclopent‐2‐ene‐1,2‐diol derivatives like 2 is a useful method for enantiodivergent functionalization, resulting in both enantiomeric series of chiral building blocks. The chiral building blocks 3 and 13 can be transformed to methyl jasmonate (1)and its unnatural enantiomer ent‐1, recent statement [1b] that 1 has no odour at all and that ‘methyl jasmonate's’ fragrance is actually due to its cis‐isomer ent‐11 has been confirmed also for the enantiomeric series.
No takes yet. Share an insight, caveat, or question.
Montforts et al. (1989) studied this question.