Basal-Cell Carcinoma of the Skin: A Harbinger of Cutaneous and Noncutaneous Multiple Primary Cancer

Editorials15 November 1996Basal-Cell Carcinoma of the Skin: A Harbinger of Cutaneous and Noncutaneous Multiple Primary CancerDavid Schottenfeld, MD, MScDavid Schottenfeld, MD, MScUniversity of Michigan School of Public Health Ann Arbor, MI 48109-2029.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-10-199611150-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Epidemiologic studies of various incidence patterns of multiple primary cancer in patients with cancer have guided research about carcinogenic mechanisms that may apply to several organ sites [1, 2]. At issue is whether risk patterns exist that predict subsequent primary cancer in patients with an index primary cancer of a particular organ and type. Also at issue is whether apparent increases in risk result from 1) shared or common etiologic factors in the pathogenesis of the index and second primary cases of cancer; 2) adverse toxic effects of agents used in the treatment of the index cancer; 3) random or ...References1. Boice JD Jr, Storm HH, Curtis RE, Jensen OM, Kleinerman RA, Jensen HS, et al. Multiple primary cancers in Connecticut and Denmark. Bethesda, MD: US Department of Health and Human Services; 1985; NIH publication no. 85-2714. Google Scholar2. Schottenfeld D. Multiple primary cancers. In: Schottenfeld D, Fraumeni JF Jr, eds. Cancer Epidemiology and Prevention. 2d ed. New York: Oxford Univ Pr; 1996:1370-87. Google Scholar3. Frisch M, Melbye M. New primary cancers after squamous cell skin cancer. Am J Epidemiol. 1995; 141:916-22. Google Scholar4. Frisch M, Hjalgrim H, Olsen JH, Melbye M. Risk for subsequent cancer after diagnosis of basal-cell carcinoma. A population-based, epidemiologic study. 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Google Scholar Author, Article, and Disclosure InformationAuthors: David Schottenfeld, MD, MScAffiliations: University of Michigan School of Public Health Ann Arbor, MI 48109-2029.Corresponding Author: David Schottenfeld, MD, MSc, The University of Michigan, School of Public Health, Department of Epidemiology, 109 Observatory Street, Ann Arbor, MI 48109-2029. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRisk for Subsequent Cancer after Diagnosis of Basal-Cell Carcinoma: A Population-Based, Epidemiologic Study Morten Frisch , Henrik Hjalgrim , Jorgen H. Olsen , and Mads Melbye Metrics Cited byMalignant eyelid tumors in Hong Kong 1997–2009Epithelial Ovarian Cancer and the Occurrence of Skin Cancer in The Netherlands: Histological Type ConnotationsSecond primary cancers in patients with skin cancer: a population-based study in Northern IrelandProtective effect from solar exposure, risk of an ecological fallacyDaily coffee consumption and prevalence of nonmelanoma skin cancer in Caucasian womenIncidence of Eyelid Cancers in TaiwanCutaneous melanoma in postmenopausal women after nonmelanoma skin carcinomaRisk of Second Primary Cancer and Death Following a Diagnosis of Nonmelanoma Skin CancerAssociation of nonmelanoma skin cancer with second malignancyTreatment of CarcinogenesisRisk of Basal Cell and Squamous Cell Carcinoma in Persons with Prior Cutaneous MelanomaBasal-cell carcinoma as predictor for other cancersStrategies in Skin Cancer Chemoprevention 15 November 1996Volume 125, Issue 10 Page: 852-854 Keywords Cancer epidemiology Cancer risk factors Cancer treatment Lung and intrathoracic tumors Lymphoma Medical risk factors Melanoma Relative risk Risk management Salivary gland tumors ePublished: 15 August 2000 Issue Published: 15 November 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. 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