This experiment tested the capacity of a calf-skin collagen-mineral gel to induce bone regeneration within surgically-created periodontal defects in one dog and four monkeys. No bone regeneration occurred within 8 to 14 weeks. Healing primarily consisted of soft connective tissue formation and re-epithelialization. Notched defects on root surfaces did not repair with cementum and were always foci of inflammation.
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Levy et al. (1981) studied this question.
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