Novel Frostbite Cooling Device for Real-time Assessment and Prevention of Chemotherapy-induced Peripheral Neuropathy

Figures

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  Fig. 1.. The CECS boasts a very slender profile, measuring only 4 mm of thickness, and features lightweight construction, tipping the scales at 640 g. This state-of-the-art seat incorporates an innovative water circulation system. The temperature control span ranges from 15° to 41°C, with the ongoing water circulation guaranteeing steadfast temperature management. Notably, the overall device weight was 1700 g, confirming its exceptional portability.

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  Fig. 2.. The GOKO Bscan-ZD videocapillaroscope served as the apparatus for observing capillaries in the skin flap. The camera field covered 0.35 mm²/point, reaching a depth of 1mm from the surface. Remarkably lightweight at 140 g, it allowed for effortless single-handed operation. The observations were conducted at approximately 175× and 620× magnification, boasting a resolution of 1.2 million pixels.

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  Fig. 3.. Cooling was executed, utilizing docetaxel administration as the conceptual framework, encompassing a total cooling duration of 2.5 hours. This cooling protocol comprised a 30-minute predose cooling phase, simultaneous cooling throughout the entire period of docetaxel administration (1 h), and postadministration cooling lasting approximately 1 hours. The primary objective of this investigation was to assess the impact of the cooling regimen on the half-life (t₁/₂) of docetaxel.

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  Fig. 4.. The cooling procedure reduced the hand surface temperature from 36.4° to 23.4°C and significantly reduced the vascular area. Similarly, the finger surface temperature decreased from 36.5° to 22.5°C, and the vascular area decreased significantly.

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  Fig. 5.. A remarkable shift commenced at an initial superficial finger temperature of 36.129° ± 0.299°C, demonstrating a significant decrease to 24.043° ± 1.735°C postcooling. This compelling thermal modulation underscores the cooling intervention’s efficacy, resulting in a noteworthy reduction in the surface temperature of both hands and fingers.

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  Fig. 6.. The initial blood vessel area shifted substantially from 11.2% ± 2.88% before cooling to 3.848% ± 1.621% postcooling (P < 0.001). Cooling reduced the vascular area significantly in the hands and fingers.