Effects of endothelium-derived nitric oxide on skin and digital blood flow in humans

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Why the study?

Does L-NMMA infusion alter skin and digital blood flow in normal subjects during basal state and reflex sympathetic vasoconstriction?

Structured PICO

Does L-NMMA infusion alter skin and digital blood flow in normal subjects during basal state and reflex sympathetic vasoconstriction?

Population

Normal subjects

Intervention

NG-monomethyl-L-arginine (L-NMMA) in doses of 2, 4, and 8 microM/min given by constant infusion via a brachial artery catheter

Comparator

Basal state (pre-infusion) and body cooling without L-NMMA

Outcome

Total finger and forearm blood flows, and dorsal finger and forearm skin blood flowssurrogate

Nitric oxide contributes to the basal dilator tone of the dorsal finger and forearm skin, but not during reflex sympathetic vasoconstriction.

Authors

No takes yet. Share an insight, caveat, or question.

Does not support changes in clinical skin perfusion management; leaves open nitric oxide's role in basal versus reflex cutaneous flow.

J D Coffman (1994) studied this question.

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