Nsaid-Induced Polyp Regression in Familial Adenomatous Polyposis Patients

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin synthesis.In 1983, Waddell and Loughry62 first reported that sulindac (Clinoril) caused regression of rectal adenomatous polyps in several patients with familial adenomatous polyposis (FAP) (an inherited form of colorectal cancer).Over the past decade, this initial report has been supported by the use of NSAIDs in animal carcinogenesis models.Moreover, adenoma regression has been confirmed by anecdotal and controlled human studies.The mechanism of colorectal neoplasia chemoprevention by NSAIDs is unknown, although several hypotheses have been advanced. . FAMILIAL ADENOMATOUS POLYPOSISColorectal adenoma regression has been demonstrated primarily in patients with FAP.FAP is an autosomal dominant syndrome caused by a germline mutation of the adenomatous polyposis coli (APC) gene located on chromosome 5q.I8, 36 Teenaged patients develop hundreds to This work was supported by Grant No.