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A statistical study of the incidence and specificity of multiple irregular blood group antibodies shows predominance of those within the Rh‐Hr, Kell, and Duffy systems. When multiple antibodies included those in the Lewis, Lutheran, MNS, P, or Kidd systems, the other antibodies were usually in the Rh‐Hr, Kell, and Duffy systems. The following categories of donors: 1a Group O Rh‐neg. (dce/dce) K‐neg. Fya‐neg. 1b Group O Rh‐neg. (dce/dce) K‐neg. Fyb‐neg. 2a Group O Rh‐pos. (R1R1‐DCe) K‐neg. Fya‐neg. 2b Group O Rh‐pos. (R1R1‐DCe/DCe) K‐neg. Fyb‐neg. 3a Group O Rh‐pos. (R2R2‐DcE7DcE) K‐neg. Fya‐neg. 3b Group O Rh‐pos. (R2R2‐DcE/DcE) K‐neg. Fyb‐neg. are further subtyped for Lea, Leb, P, Jka, Jkb, M, N, S, s, and Lua. Erythrocytes from these donors, frozen in glycerol, with Anti‐A, and Anti‐B antibodies removed during deglycerolization simplifies the problem of finding compatible blood for patients with multiple antibodies.
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Grove‐Rasmussen et al. (1973) studied this question.
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