Hemolytic Transfusion Reaction Associated With the Transfusion of "Dangerous Universal Donor" Blood

Case Reports1 December 1955HEMOLYTIC TRANSFUSION REACTION ASSOCIATED WITH THE TRANSFUSION OF "DANGEROUS UNIVERSAL DONOR" BLOODHUGH CHAPLIN JR., M.D.HUGH CHAPLIN JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-6-1334 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe hazards of "dangerous universal donor" blood have received considerable attention in recent years. Because of increasing awareness of this problem, and in the light of occasional serious and even fatal reactions caused by the emergency transfusion of blood or plasma containing high anti-A or anti-B antibody titers,1-6it has been recommended that some sort of screening procedure be employed in the selection of Group O blood suitable for transfusion to heterospecific recipients. A procedure commonly used is to test the capacity of the donor's serum diluted 1/200 in saline to agglutinate an equal volume of 2% saline suspension of...Bibliography1. Albertson EC: Fatality due to transfusion of unpooled plasma, Am. J. Clin. Path. 15: 128, 1945. CrossrefGoogle Scholar2. EbertEmerson RVCP: A clinical study of transfusion reactions. The hemolytic effect of Group O blood and pooled plasma containing incompatible isoagglutinins, J. Clin. Investigation 25: 627, 1946. CrossrefMedlineGoogle Scholar3. ErvinYoung DMLE: Dangerous universal donors. I. Observations on destruction of recipient's A cells after transfusion of group O blood containing high titer of A antibodies of immune type not easily neutralizable by soluble A substance, Blood 5: 61, 1950. CrossrefMedlineGoogle Scholar4. ErvinChristianYoung DMRMLE: Dangerous universal donors. II. Further observations on in vivo and in vitro behavior of isoantibodies of immune type present in group O blood, Blood 5: 553, 1950. CrossrefMedlineGoogle Scholar5. WeinerMoloney ASWC: Hemolytic transfusion reactions. IV. Differential diagnosis "dangerous universal donor" or intragroup incompatibility, Am. J. Clin. Path. 13: 74, 1943. CrossrefGoogle Scholar6. StevensFinch ARCA: A dangerous universal donor, Am. J. Clin. Path. 24: 612, 1954. CrossrefMedlineGoogle Scholar7. BoormanDodd KEBE: An incomplete form of A agglutinin, Nature, London 158: 589, 1946. CrossrefMedlineGoogle Scholar8. CrawfordCutbushFalconerMollison HMHPL: The formation of immune A iso-antibodies, with special reference to heterogenetic-stimuli, Lancet 2: 219, 1952. CrossrefMedlineGoogle Scholar9. DaussetVidal JG: Accidents de la transfusion chez des des receveurs de groupe A ayant reçu du sang de groupe O; rôle de la vaccination par l'anatoxine diphterique et tétanique, Sang 22: 478, 1951. MedlineGoogle Scholar10. Grove-RasmussenShawMarceau MRSE: Hemolytic transfusion reaction in a group-A patient receiving group O blood, Am. J. Clin. Path. 23: 828, 1953. CrossrefMedlineGoogle Scholar11. Davidsohn I: Isoagglutinin titers in serum disease, in leukemias, in infectious mononucleosis, and after blood transfusions, Am. J. Clin. Path. 8: 179, 1938. CrossrefGoogle Scholar12. DacieMollison JVPL: Survival of normal erythrocytes after transfusion to patients with familial haemolytic anemia, Lancet 1: 550, 1943. CrossrefGoogle Scholar13. Grove-RasmussenSoutterMarceau MLE: The use of group O donors as "universal donors," Proceedings, Fourth Annual Meeting, American Association of Blood Banks, October, 1951. Google Scholar14. CrosbyAckeroyd WHJH: Some immunohematologic results of large transfusions of group O blood in recipients of other groups. A study of battle casualties in Korea, Blood 9: 103, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Maryland*Received for publication October 1, 1954.From the National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRisks of hemolysis due to anti-A and anti-B caused by the transfusion of blood or blood components containing ABO-incompatible plasmaTransfusion de sang frais total en temps de guerre : expérience du groupement médicochirurgical Warehouse durant la période 2006–2009Severe immune haemolysis in a group A recipient of a group O red blood cell unitAcute intravascular hemolysis secondaryto out-of-group platelet transfusionComplications of Blood TransfusionLAWRENCE E. YOUNG, M.D., F.A.C.P. 1 December 1955Volume 43, Issue 6Page: 1334-1340KeywordsAnemiaBlood banksBlood donorsBlood groupsBlood plasmaBlood transfusionMedical servicesPrevention, policy, and public health ePublished: 1 December 2008 Issue Published: 1 December 1955 PDF downloadLoading ...