Population
8 cultures of fibroblasts and 2 cultures of vascular endothelial cells
Comparison
ACE substrates and inhibitors vs Comparison between fibroblast and vascular…
Design
Preclinical
Authors
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Fibroblast cultures degrade but do not generate angiotensin II unlike endothelial cells; leaves open differential roles in tissue renin-angiotensin systems.
Fibroblasts exhibit ACE-like activity that differs from vascular endothelial cells, primarily degrading rather than producing angiotensin II.
Rubin et al. (1982) studied this question.
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