Naturally radical: The microwave-induced rearrangement of sceptrin to natural products ageliferin and nagelamide E results in approximately the same ratio as they are isolated from natural sources. Computational investigations show that the vinylcyclobutane–cyclohexene rearrangement occurs via diradical intermediates and support the involvement of this rearrangement in the biosynthesis of the natural products.
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Northrop et al. (2006) studied this question.
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