Fibrinogenopenia and Fibrinolysis in Acute Myelogenous Leukemia

Case Reports1 March 1955FIBRINOGENOPENIA AND FIBRINOLYSIS IN ACUTE MYELOGENOUS LEUKEMIAARTHUR A. COOPERBERG, M.D., GREGORY M. A. NEIMAN, M.D.ARTHUR A. COOPERBERG, M.D.Search for more papers by this author, GREGORY M. A. NEIMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-3-706 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFibrinogenopenia in leukemia is a rare occurrence, according to the literature. Risak8 reported a marked fibrinogenopenia in three patients with acute myelogenous leukemia who died of severe bleeding. He assumed an impaired production of fibrinogen as the cause of the fibrinogenopenia, but tests for fibrinolysis were not carried out in these cases.In the case reported below a reduction in plasma fibrinogen was discovered in the course of examination of the blood. Further studies revealed the presence of a fibrinolysin, which was believed to be the cause of the fibrinogenopenia. In recent years the appearance of a fibrinolysin and fibrinogenopenia...Bibliography1. LewisFerguson JHJH: Studies on a proteolytic enzyme system in the blood. IV. Activation of profibrinolysin by serum fibrinolysokinase, Proc. Soc. Exper. Biol. and Med. 78: 184, 1951. CrossrefMedlineGoogle Scholar2. Lewis JH: Blood clotting and allied problems, Transactions of the Fifth Conference, 1952, Josiah Macy, Jr. Foundation, New York, p. 302. Google Scholar3. MacfarlaneBiggs RGR: Fibrinolysis. Its mechanism and significance, Blood 3: 1167, 1948. CrossrefMedlineGoogle Scholar4. MoloneyEganGorman WCWJAJ: Acquired afibrinogenemia in pregnancy, New England J. Med. 240: 596, 1949. CrossrefMedlineGoogle Scholar5. Proceedings of the Second Conference on Folic Acid Antagonists in the Treatment of Leukemia, Blood 7: 152-159, 1952. Google Scholar6. 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TagnonLevensonDavidsonTaylor HJSMCSFH: The occurrence of fibrinolysis in shock, with observations on the prothrombin time and the plasma fibrinogen during hemorrhagic shock, Am. J. M. Sc. 211: 88, 1946. CrossrefMedlineGoogle Scholar13. TagnonShulmanWhitmoreLeone HJPWFLA: Prostatic fibrinolysin, Am. J. Med. 15: 875, 1953. CrossrefMedlineGoogle Scholar14. WeinerReidRoby AEDECC: Incoagulable blood in severe premature separation of the placenta: a method of management, Am. J. Obst. and Gynec. 66: 475, 1953. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Montreal,*Received for publication April 30, 1954.From the Department of Medicine and Hematology Laboratory, Jewish General Hospital, Montreal, Canada. 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MIDDLEBROOK, M.D.Bleeding Diathesis Associated with a Circulating Fibrinolysin: Report of Three CasesAUTOERYTHROCYTE SENSITIZATION WITH A CIRCULATING FIBRINOLYTIC FACTOR 1 March 1955Volume 42, Issue 3Page: 706-711KeywordsAcute myeloid leukemiaBlood plasmaFibrinogenFibrinolysisHematology and oncologyHemorrhageHospital medicineResearch laboratories ePublished: 1 December 2008 Issue Published: 1 March 1955 PDF downloadLoading ...