Studies on the Chemotherapy of the Human Malarias. Ix. Effect of Pamaquine on the Blood Cells of Man 123

Pamaquine (6-methoxy-8-amino [N-diethylaminoisopentyl] quinoline) is recognized to be a potentially dangerous drug. However, a definitive appraisal of its hazard had not been achieved at a time when the further exploration of the antima- larial activity of the 8-aminoquinolines was con- sidered advisable. Pamaquine toxicity can in- volve the gastro-intestinal tract, the central nerv- ous system, and the circulating blood. Symptoms referable to the gastro-intestinal tract and the cen- tral nervous system may be annoying, but there is no evidence that they constitute a hazard to life or persist beyond the termination of therapy. Effects on the blood do constitute a serious hazard and are considered in this paper.