Radiation-Induced Adaptive Responses and Bystander Effects

A classical paradigm [correction of paradym] of radiation biology asserts that all radiation effects on cells, tissues and organisms are due to the direct action of radiation. However, there has been a recent growth of interest in the indirect actions of radiation including the radiation-induced adaptive response, the bystander effect, low-dose hypersensitivity, and genomic instability, which are specific modes of stress exhibited in response to low-dose/low-dose rate radiation. This review focuses on the radiation-induced bystander effect and the adaptive response, provides a description of the two phenomena, and discusses the contribution of the former to the latter.