Serum hepatitis occurred in 19 of 43 hemodialysis patients who received whole blood or packed cells before institution of the exclusive use of reconstituted frozen erythrocytes for transfusion. These patients received an average of 12.5 units of blood during 9.5 months before developing hepatitis. In contrast, only one case of hepatitis developed in a group of 13 patients who received nothing but reconstituted frozen erythrocytes. They received an average of 11 units of frozen cells during 13 months. Patients who received no blood had no hepatitis. The exclusive use of reconstituted frozen erythrocytes leads to a marked decrease in the incidence of hepatitis in dialysis units.
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Jillian B. Carr (1973) studied this question.
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