Experimental Exophthalmos and Associated Myopathy Induced by the Thyrotropic Hormone

Article1 September 1941EXPERIMENTAL EXOPHTHALMOS AND ASSOCIATED MYOPATHY INDUCED BY THE THYROTROPIC HORMONEROBERT B. AIRD, M.D.ROBERT B. AIRD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-3-564 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe term "malignant exophthalmos" designates the progressive and alarming proptosis which occurs in a small group, usually after thyroidectomy and in the presence of a low basal metabolic rate. Unless relieved by operative decompression of the bony orbit, as devised by Naffziger,1a high percentage of these patients develop corneal ulceration, infection, and fatal intracranial extension of the orbital cellulitis. The pathologic changes and immediate cause of the exophthalmos occurring in these patients were described in detail in previous reports.1In brief, the extraocular muscles were found to be enlarged from three to eight times. Grossly, the musculature of the...References1. NAFFZIGER HC (a) : Progressive exophthalmos following thyroidectomy; its pathology and treatment, Ann. Surg., 1931, xciv, 582-586. CrossrefGoogle Scholar NAFFZIGERJONES HCOW (b) : The surgical treatment of progressive exophthalmos following thyroidectomy, Jr. Am. Med. Assoc., 1932, xcix, 638-642. CrossrefGoogle Scholar NAFFZIGER HC (c) : Pathologic changes in the orbit in progressive exophthalmos, Arch. Ophth., 1933, ix, 1-11. CrossrefGoogle Scholar NAFFZIGER HC (d) : Progressive exophthalmos associated with disorders of the thyroid gland, Ann. Surg., 1938, cviii, 529-544. CrossrefGoogle Scholar2. AIRD RB: Experimental exophthalmos and the associated myopathy induced by the thyrotropic hormone, Arch. 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CrossrefGoogle Scholar GINSBURG S (c) : Postoperative progressive exophthalmos with low basal metabolic rate, ANN. INT. MED., 1939, xiii, 424-450. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Received for publication March 27, 1941.From the Department of Surgery, University of California Medical School.This work was conducted under grants from the Christine Breon Fund for Medical Research. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Beeinflussung des tierexperimentellen Exophthalmus durch verschiedene HormoneLiteraturEndocrine ExophthalmosEnhancing Effect of Corticotrophin*Malignant Exophthalmos*Pituitary Exophthalmos : An Assessment of Methods of TreatmentExophthalmos in the light of current anti-thyroid therapyThe Chemistry and Physiology of the Thyroid HormoneExophthalmos 1 September 1941Volume 15, Issue 3Page: 564-581KeywordsCellulitisHormonesMusclesResearch fundingSurgeryThyroidectomyUlcers ePublished: 1 December 2008 Issue Published: 1 September 1941 PDF downloadLoading ...