Polyampholytes, prepared by copolymerization of 2‐(N,N‐dimethylamino)ethyl methacrylate and methacrylic acid, increase the urease activity over a large pH range, when the acid content is between 24 and 68 mol‐%, while the activity of the enzyme is inhibited by polyampholytes having more than 84 mol‐% of methacrylic acid groups. The enzyme reaction induces conformational changes of the polyampholyte chain resulting from a pH increase due to the formation of ammonium carbonate. The contraction of the macromolecule was followed by viscometry and by the volume change of a cross‐linked analogous polyampholyte gel.
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Dupommier et al. (1986) studied this question.
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