A technic is described for simultaneous determination in man of equilibration of cholesterol with bile acids and of bile acid turnover. Two hypercholesterolemic patients on formula diets containing synthetic fats showed prolonged bile acid half-lives with decelerated cholesterol degradation; cholic acid production was only 0.09 g per day (4-fold reduction from normal levels). Deoxycholic acid was totally absent from the bile in one case.
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Lindstedt et al. (1961) studied this question.