Design and Biomedical Applications of Poly(amidoamine)‐Dendrimer‐Based Hybrid Nanoarchitectures

Dendrimers, especially poly(amidoamine) (PAMAM) dendrimers, possess unique properties such as 3D architecture, monodispersity, highly branched macromolecular characteristics, and tunable terminal functionalities. These properties allow them to be used for controlled synthesis and assembly of hybrid nanoarchitectures with a range of properties suitable for biomedical applications. Here, the recent advances in the design of different PAMAM‐dendrimer‐based hybrid nanoarchitectures for various biomedical applications, in particular for molecular imaging, nonviral gene delivery, and theranostics, are summarized and discussed; future perspectives are also briefly illustrated.