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Escherichia coli was transformed with a pUC 19 plasmid which contained a 4,5′,8‐trimethylpsoralen cross‐link specifically at position T410‐A411, and transformants in which the cross‐link had been repaired were scored on the basis of ampicillin resistance. Repair was only seen after induction of the SOS‐system by shortwave ultraviolet irradiation. The repair efficiency was 6%, and of 100 colonies analyzed only two was found to be mutated at the cross‐linked site: a T‐A transversion was observed at position 410. A repair mechanism which does not involve recombination is proposed.
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Zhen et al. (1986) studied this question.
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